The manuscript associated with the current version of

isRosenberg, M.S. (2024) MetaWin 3: Open-source software for meta-analysisFrontiers in Bioinformatics4:1305969. DOI: 10.3389/fbinf.2024.1305969

### A Brief History

Rosenberg *et al.* 1997)
was first published as a small, commercial piece of software that made meta-analytical calculations
more accessible to the burgeoning research synthesis community, particularly in the ecological
sciences, and helped introduce the use of resampling methods into the meta-analytic statistical
repertoire (Adams *et al.* 1997).

Version 2 of the software (Rosenberg *et al.* 2000) was
substantially expanded over the original version, easier to use, and more flexible and powerful.

The original versions of

were written in Pascal and Delphi and depended on a number of commercially licensed packages. These developmental environments combined to functionally restrict the software to the Windows operating system and prevented any practial open source release as the software was otherwise uncompilable without these components. These also restricted further development and updates as the developmental components and systems gradually became incompatible with newer operating systems.Despite these limitations,

2 continued to be regularly used and cited decades after its original release.## Primary Features

- Calculating Effect Sizes
- Pairs of Means
- Hedges'
*d* - ln Response Ratio

- Hedges'
- Two × Two Contingency Table
- ln Odds Ratio
- Rate Difference
- ln Relative Rate

- Correlation Coefficients
- Fisher's
*Z*-transform

- Fisher's
- Probabilities
- Logit

- Pairs of Means
- Publication Bias
- Funnel Plot
- Egger Regression
- Rank Correlation Analysis
- Trim and Fill Analysis

- Analyses
- Basic Meta-Analysis
- Jackknife Meta-Analysis
- Cumulative Meta-Analysis
- Grouped Meta-Analysis
- Nested Group Meta-Analysis
- Linear Meta-Regression Analysis
- Complex/GLM Meta-Analysis
- Phylogenetic GLM Meta-Analysis

- Additional Graphs and Figures
- Scatter/Funnel Plot
- Weighted Histogram
- Forest Plot
- Normal Quantile Plot
- Galbraith (Radial) Plot